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Laboratory of Dr. Ivy Dick
Lab News
Audra Kramer receives a Maryland Stem Cell Research Fund Post-doctoral Fellowship
Congratulations to Audra on her 2023-2025 Postdoctoral Fellowship Award from the Maryland Stem Cell Research Fund for her proposal 'Evaluating the Pathogenic Mechanisms Underlying CACNA1A Disorders'. The project explores the impact of altered CaV2.1 function in the context of iPSC derived neurons, enabling new mechanistic understanding of CACANA1A disorders.
Ivy Dick wins the 2022 Paul F. Cranefield Award
The Paul F. Cranefield Award was given to Ivy Dick by the Society of General Physiologists for the paper 'CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms' published in the Journal of General Physiology. This work shows that differential effects on channel gating may underlie the cardiac vs. neurological phenotypes of Cav1.2 mutations. This is an important step to understand the pathogenesis of these mutations, and paves the way for future therapeutics.
Daiana C.O. Vieira Wins Top Poster Award
Congratulations to Daiana who earned the first-place postdoctoral poster award at the 2022 Society of General Physiologists conference held in Woods Hole. Her poster, 'LQT8 mutations induce action potential prolongation and arrhythmia in induced pluripotent stem cell derived cardiomyocytes', utilized CRISPR-induced Cav1.2 mutations in iPSC derived cardiomyocytes to demonstrate the pathogenic mechanism underlying LQT8, and propose a promising new treatment strategy for the disease.
Daiana C.O. Vieira Wins The 2022 Postdoctoral Fellow Excellence in Mentorship Award
Congratulations to Daiana who received the 2022 Postdoctoral Excellence in Mentorship Award from the University of Maryland School of Medicine for her outstanding record of mentorship. She was nominated by her lab-mates, who thanked her for being an inspirational and outstanding teacher and mentor.
Mutations in Calmodulin May Impact the Conviction of Kathleen Folbigg
In 2003 Kathleen Folbigg was convicted of murdering her four children, each of whom died of unknown causes before the age of two. However, new genetic evidence demonstrates that Folbigg and two of her children harbor a potentially pathogenic mutation within a gene encoding calmodulin, a ubiquitous calcium sensor which is critical in the normal function of the heart. Dr. Ivy Dick was part of an international research collaboration led by Drs. Schwartz, Overgaard and Vinuesa which demonstrated the potential pathogenetic effects of the mutation, leading to a new inquiry into the case.
Daiana C.O. Vieira Receives an AHA Postdoctoral Fellowship
Congratulations to Daiana on her 2022-2023 Postdoctoral Fellowship Award from the American Heart Association for her proposal 'Spatial heterogeneity in CaV1.2 alternative splicing contributes to LQT8 Arrhythmogenesis'. The project explores the impact of alternative splicing of Cav1.2 in the heart on the pathogenesis of of Long-QT syndrome, and explores the impact of splice variation in cardiac tissue on treatment.
Moradeke Bomgboye Receives an AHA Postdoctoral Fellowship
Congratulations to Mora, who received a 2020-2021 Postdoctoral Fellowship Award from the American Heart Association for her proposal 'Probing the pathogenic mechanisms underlying Long-QT type 8'. The grant received an impressive 0.1% score!!
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