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Laboratory of Dr. Ivy Dick
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Highlighted Publications
Impaired CaV1.2 inactivation reduces the efficacy of calcium channel blockers in the treatment of LQT8
Journal of Molecular and Cellular Cardiology
Moradeke A. Bamgboye, Maria K. Traficante, Josiah Owoyemi, Deborah DiSilvestre, Daiana C.O. Vieira and Ivy E. Dick


CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms
Journal of General Physiology
Moradeke A. Bamgboye, Kevin G. Herold, Daiana C.O. Vieira, Maria K. Traficante, Pippa. J. Rogers, Manu Ben-Johny and Ivy E. Dick
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Hussey, J. W., Limpitikul, W. B. & Dick, I. E., Calmodulin Mutations in Human Disease, Channels (Austin). 2023 Dec; 17(1): 2165278.
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Hussey, J. W., Herold, K. G. & Dick, I. E. Voltage-gated calcium channelopathies. Calcium Signals: From Single Molecules to Physiology (eds Les Satin, Manu Ben Johny, & Ivy Dick) IOP. 2023; Vol. 4 Ch. 13,. *selected cover image
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Herold, K. G., Hussey, J. W. & Dick, I. E., CACNA1C-Related Channelopathies, Handb Exp Pharmacol. 2023 Jan 5; doi: 10.1007/164_2022_624.
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Ben-Johny, M. & Dick, I. E. Calmodulin Regulation of Voltage-Gated Calcium Channels in Voltage-Gated Calcium Channels (ed G. W. Zamponi, Weiss, N. ) Springer, Cham., 2022.
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Chakouri, N., Rivas, S., Roybal, D., Yang, L., Diaz, J., Hsu, A., Mahling, R., Chen, B. X., Owoyemi, J. O., DiSilvestre, D., Sirabella, D., Corneo, B., Tomaselli, G. F., Dick, I. E., Marx, S. O. & Ben-Johny, M., Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current, Nat Cardiovasc Res. 2022 May; 1(5): 1-13.
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Sang, L., Vieira, D. C. O., Yue, D. T., Ben-Johny, M. & Dick, I. E., The molecular basis of the inhibition of CaV1 calcium-dependent inactivation by the distal carboxy tail, J Biol Chem. 2021 Jan-Jun; 296 100502.
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Brohus, M., Arsov, T., Wallace, D. A., Jensen, H. H., Nyegaard, M., Crotti, L., Adamski, M., Zhang, Y., Field, M. A., Athanasopoulos, V., Baro, I., Ribeiro de Oliveira-Mendes, B. B., Redon, R., Charpentier, F., Raju, H., DiSilvestre, D., Wei, J., Wang, R., Rafehi, H., Kaspi, A., Bahlo, M., Dick, I. E., Chen, S. R. W., Cook, M. C., Vinuesa, C. G., Overgaard, M. T. & Schwartz, P. J., Infanticide vs. inherited cardiac arrhythmias, Europace. 2021 Mar 8; 23(3): 441-450. News
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Niu, J., Dick, I. E., Yang, W., Bamgboye, M. A., Yue, D. T., Tomaselli, G., Inoue, T. & Ben-Johny, M., Allosteric regulators selectively prevent Ca(2+)-feedback of CaV and NaV channels, Elife. 2018 Sep 10; 7 e35222.
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Limpitikul, W. B., Greenstein, J. L., Yue, D. T., Dick, I. E. & Winslow, R. L., A bilobal model of Ca(2+)-dependent inactivation to probe the physiology of L-type Ca(2+) channels, J Gen Physiol. 2018 Dec 3; 150(12): 1688-1701.
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Limpitikul, W. B., Dick, I. E., Tester, D. J., Boczek, N. J., Limphong, P., Yang, W., Choi, M. H., Babich, J., DiSilvestre, D., Kanter, R. J., Tomaselli, G. F., Ackerman, M. J. & Yue, D. T., A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome, Circ Res. 2017 Jan 06; 120(1): 39-48. Commentary
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Niu, J., Ben Johny, M., Dick, I. E. & Inoue, T., Following Optogenetic Dimerizers and Quantitative Prospects, Biophys J. 2016 Aug 16; 6 1132-1140.
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Sang, L., Dick, I. E. & Yue, D. T., Protein kinase A modulation of CaV1.4 calcium channels, Nat Commun. 2016 July; 7 12239.
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Limpitikul, W. B., Dick, I. E., Ben-Johny, M. & Yue, D. T., An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca(2+)-dependent regulation, Sci Rep. 2016 Jun; 6 27235.
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Dick, I. E., Limpitikul, W. B., Niu, J., Banerjee, R., Issa, J. B., Ben-Johny, M., Adams, P. J., Kang, P. W., Lee, S. R., Sang, L., Yang, W., Babich, J., Zhang, M., Bazazzi, H., Yue, N. C. & Tomaselli, G. F., A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory, Channels (Austin). 2016 Jan/Feb; 10(1): 20-32.
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Dick, I. E., Joshi-Mukherjee, R., Yang, W. & Yue, D. T., Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca(2+)-dependent inactivation, Nat Commun. 2016 Jan 29; 7 10370.
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Ben-Johny, M., Dick, I. E., Sang, L., Limpitikul, W. B., Kang, P. W., Niu, J., Banerjee, R., Yang, W., Babich, J. S., Issa, J. B., Lee, S. R., Namkung, H., Li, J., Zhang, M., Yang, P. S., Bazzazi, H., Adams, P. J., Joshi-Mukherjee, R., Yue, D. N. & Yue, D. T., Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels, Curr Mol Pharmacol. 2015 July; 8(2): 188-205.
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Bazzazi, H., Sang, L., Dick, I. E., Joshi-Mukherjee, R., Yang, W. & Yue, D. T., Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes, J Physiol. 2015 Sep 1; 593(17): 3865-3884.
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Bazzazi, H., Sang, L., Dick, I. E., Joshi-Mukherjee, R., Yang, W. & Yue, D. T., Novel FRET-based Reporter Reveals Differential Calcineurin Activation in Neonatal and Adult Cardiomyocytes, J Physiol. 2015 Sept; 593(17): 3865-3884.
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Limpitikul, W. B., Dick, I. E., Joshi-Mukherjee, R., Overgaard, M. T., George, A. L., Jr. & Yue, D. T., Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes, J Mol Cell Cardiol. 2014 Sep; 74 115-124.
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Adams, P. J., Ben-Johny, M., Dick, I. E., Inoue, T. & Yue, D. T., Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation, Cell. 2014 Oct 23; 159(3): 608-622.
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Joshi-Mukherjee, R., Dick, I. E., Liu, T., O'Rourke, B., Yue, D. T. & Tung, L., Structural and functional plasticity in long-term cultures of adult ventricular myocytes, J Mol Cell Cardiol. 2013 Dec; 65 76-87.
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Tay, L. H., Dick, I. E., Yang, W., Mank, M., Griesbeck, O. & Yue, D. T., Nanodomain Ca(2)(+) of Ca(2)(+) channels detected by a tethered genetically encoded Ca(2)(+) sensor, Nat Commun. 2012 3 778.
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Tadross, M. R., Dick, I. E. & Yue, D. T., Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel, Cell. 2008 Jun 27; 133(7): 1228-1240.
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Dick, I. E., Tadross, M. R., Liang, H., Tay, L. H., Yang, W. & Yue, D. T., A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels, Nature. 2008 Feb 14; 451(7180): 830-834.
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Liu, C. J., Priest, B. T., Bugianesi, R. M., Dulski, P. M., Felix, J. P., Dick, I. E., Brochu, R. M., Knaus, H. G., Middleton, R. E., Kaczorowski, G. J., Slaughter, R. S., Garcia, M. L. & Kohler, M. G., A high-capacity membrane potential FRET-based assay for NaV1.8 channels, Assay Drug Dev Technol. 2006 Feb; 4(1): 37-48.
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Brochu, R. M., Dick, I. E., Tarpley, J. W., McGowan, E., Gunner, D., Herrington, J., Shao, P. P., Ok, D., Li, C., Parsons, W. H., Stump, G. L., Regan, C. P., Lynch, J. J., Jr., Lyons, K. A., McManus, O. B., Clark, S., Ali, Z., Kaczorowski, G. J., Martin, W. J. & Priest, B. T., Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats, Mol Pharmacol. 2006 Mar; 69(3): 823-832.
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Liang, J., Brochu, R. M., Cohen, C. J., Dick, I. E., Felix, J. P., Fisher, M. H., Garcia, M. L., Kaczorowski, G. J., Lyons, K. A., Meinke, P. T., Priest, B. T., Schmalhofer, W. A., Smith, M. M., Tarpley, J. W., Williams, B. S., Martin, W. J. & Parsons, W. H., Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain, Bioorg Med Chem Lett. 2005 Jun 2; 15(11): 2943-2947.
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Herrington, J., Sanchez, M., Wunderler, D., Yan, L., Bugianesi, R. M., Dick, I. E., Clark, S. A., Brochu, R. M., Priest, B. T., Kohler, M. G. & McManus, O. B., Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells, J Physiol. 2005 Aug 15; 567(Pt 1): 159-175.
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Priest, B. T., Garcia, M. L., Middleton, R. E., Brochu, R. M., Clark, S., Dai, G., Dick, I. E., Felix, J. P., Liu, C. J., Reiseter, B. S., Schmalhofer, W. A., Shao, P. P., Tang, Y. S., Chou, M. Z., Kohler, M. G., Smith, M. M., Warren, V. A., Williams, B. S., Cohen, C. J., Martin, W. J., Meinke, P. T., Parsons, W. H., Wafford, K. A. & Kaczorowski, G. J., A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model, Biochemistry. 2004 Aug 3; 43(30): 9866-9876.
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Felix, J. P., Williams, B. S., Priest, B. T., Brochu, R. M., Dick, I. E., Warren, V. A., Yan, L., Slaughter, R. S., Kaczorowski, G. J., Smith, M. M. & Garcia, M. L., Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes, Assay Drug Dev Technol. 2004 Jun; 2(3): 260-268.
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Smith, H. A., Church, J., Fournier, J., Lisle, J., Gay, P., Kolenberg, K., Carnery, B. W., Dick, I. E., Peterson, R. & Hakes, B., The Blazhko Effect of RR Lyrae in 1996, Publ. Astron. Soc. Pacific. 2003 (115): 43-48.
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